Substance in Fried Foods May Not Be a Risk for Breast Cancer

There appears to be little or no link between breast cancer and acrylamide, a substance found in many baked and fried foods, say researchers at an American Chemical Society (ACS) meeting.

Researcher Lorelei Mucci, Sc.D., at Harvard Medical School says this large study shows acrylamide in the diet does not appear to be an important breast cancer risk factor.

"We probably couldn't rule out that eating very high levels of acrylamide is associated with a very, very small increase in risk,” Dr. Mucci says.

“But in terms of it being an important public health risk factor for breast cancer I don't think acrylamide is a major risk factor.”

Acrylamide Forms During Cooking Process

Dr. Mucci’s study is one of 40 studies exploring various facets of a possible association between acrylamide and cancer.

The substance forms naturally during the cooking process of mostly carbohydrate-rich foods such as potato chips, french fries, breads, cereals, and even coffee.

Even though the data on human health has remained unclear, food safety authorities in Europe have started to curb acrylamide in foods.

According to the study authors, about 30 percent of calories consumed among US and European populations contain acrylamide. The average adult consumption is 0.5 micrograms per kilogram of body weight per day. Children consume higher levels.

For the current study, Dr. Mucci and her colleagues followed a group of 100,000 US nurses over a 20-year period. Participants periodically answered questionnaires about their dietary habits. This information was used to estimate daily acrylamide intake, which was then correlated with breast cancer incidence.

The result: The incidence of breast cancer among women with a high acrylamide intake was about the same as women with low intakes.

That corresponds with findings from a previous study (also by Dr. Mucci) of Swedish women that also showed no association between dietary acrylamide and risk of breast cancer. The largest source of dietary acrylamide in US women is french fries, while in Swedish women it is coffee.

A third study, conducted in Italy, also found no link.

"At the moment, I don't think there is any clear connection between acrylamide and breast cancer," says Shiuan Chen, Ph.D., at City of Hope Cancer Center in Duarte, California.

Avoid Fried Foods to Prevent Obesity

Robert Tardiff, Ph.D., an advisor to the Food Products Association, says, "I thought the results were gratifying."

"Here is an example of a situation which caused a great deal of concern based on laboratory studies, and now we have a reasonably definitive study showing that there's no link between acrylamide consumption and breast cancer,” notes Dr. Tardiff. “So, that's great.”

The association between acrylamide and breast cancer found in animal studies could be explained by the high levels of acrylamide they consumed, or by differences in how acrylamide is metabolized in the body, the experts say.

This is not likely to close the door on research into acrylamide, however.

"The food industry has been spending a lot of time and research on how to avoid acrylamide formation in food, and toxicologists are still very interested in looking at acrylamide," explains Dr. Mucci.

"There's also a new animal study with rats and mice looking at very high levels of acrylamide and cancer risk,” she says. “There's been concern whether acrylamide could have some impact on hormonal levels, so we would want to look at endometrial and ovarian cancer, because they are hormone-driven."

Dr. Tardiff adds, "One of the issues that we are working on, and that we think is particularly promising, is that there is significant detoxification of acrylamide quickly [in the human body], so it is no longer available at the levels we found in food. That research will be finished in the next couple of months."

Dr. Mucci also presented data at the ACS meeting on prostate cancer and acrylamide, where she reported no link.

But cancer is not the only reason to avoid certain foods.

"We want to think about our overall health, and there are a lot of reasons to have a low-fat diet and maintain a healthy weight," Dr. Mucci points out. "Obesity is a risk factor for so many diseases. Eat a sensible diet, don't eat too much of one thing. If you get a diverse diet, you're probably going to be protecting yourself."

Dr. Chen adds, "Environmental exposures have a lot of influence on cancer, including breast cancer, and that includes diet. Diversify your diet. Eating french fries once in a while is probably OK, but not three times a day."

Always consult your physician for more information.